Orthobiologics are natural substances such as cells, tissue, blood components, and growth factors that are harnessed to aid in the treatment of orthopedic injuries or conditions. They may be used to replace lost tissue, stimulate regeneration and healing, reduce pain and inflammation, and improve joint function.
Our blood consists of a liquid component known as plasma. It also consists of three main solid components which include the red blood cells (RBCs), white blood cells (WBCs), and platelets. Platelets play an important role in forming blood clots. They also consist of special proteins, known as growth factors, which help with our body’s healing process. Platelet-rich plasma or PRP is a high concentration of platelets and plasma. A normal blood specimen contains only 6% platelets, while platelet-rich plasma contains 94% of platelets and 5 to 10 times the concentration of growth factors found in normal blood, thus greater healing properties.
Xiaflex is a prescription medicine used to treat adults with Dupuytrens contractures. Xiaflex collagenase is an enzyme derived from the bacterium clostridum histolticum that hydrolyzes the collagen cords causing the cords to cleave into fragments and rapidly dissolve/degrade. Xiaflex is currently the only FDA approved collagenase on the market.
Viscosupplementation refers to the injection of a hyaluronan preparation into the joint. Hyaluronan is a natural substance present in the joint fluid that assists in lubrication. It allows the smooth movement of the cartilage-covered articulating surfaces of the joint.